No, you cannot work in the US with a US Tourist Visa. A B1/B2 tourist visa does not permit any kind of work activity. The visa exists to facilitate tourism activities along with family visits and medical care and short-term business conferences. Performing any paid job or unauthorized work activities leads to immediate visa termination followed by deportation and permanent entry bans. The H-1B represents the appropriate work visa that applicants must pursue to obtain employment authorization in the United States.