Yes, you can apply for Express Entry even with a lower CRS score, as long as you meet the minimum eligibility requirements of one of the three programs: Federal Skilled Worker, Skilled Trades, or Canadian Experience Class. However, with a lower CRS score, your chances of being selected in a general draw decrease. To improve your odds, you can target provincial nomination programs, pursue a valid job offer in Canada, or boost your language results. Many candidates with modest CRS scores succeed by leveraging alternative streams, demonstrating that a lower score does not eliminate your chances entirely.